Private answer
We do not use flea and tick collars at the Sanctuary. We use oral flea and tick control on our dogs. I do not know of any specific contraindication between Seresto collars and prednisone. Please discuss this with your pet's veterinarian. In an article in the AVMA Journal published in May 2021 Seresto has come under close scrutiny by the EPA. Most experts agree it is safe to use but careful consideration should be made by your veterinarian.
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